「Antidote」自分用リファレンスです。
Serotonin syndrome -> benzodiazepines -> if failed -> cyproheptadine (anti-histamine/5-HT1A/5-HT2A antagonist, 1st generation, moderate potent, potent serotonin antagonist) — serotonine syndrome may occurr when dose was increased, or when combined with new med (<-more common)
Tylenol (acetaminophen) -> Acetylcysteine
TCA (tricyclic antidepressant) – imipramine, amitriptyline。Long QT-interval or severe case が認められた時はsodium bicarbonate。TCA-overdoseによるconvulsantsには、benzodiazepines。
Benzodiazepine overdose -> Flumazenil
Opiate -> Naloxone
Heparin & LMWH (Low Molecular-Weight Heparin) -> protamine sulfate
Warfarin -> Vitamin K (IV)(PO) – kicks in 1 hour. if quicker effect is needed, fresh frozon prasma または、Vitamin K入りのprothrombin。
NSAID -> 特にantidoteは無いが、acidosisに対しては、sodium bicarbonate。
Reference
Buttaro, T. M. et al. (2021). Primary care: Interprofessional collaborative practice (6th ed.). Elsevier.
Tsai, V. (2023). Tricyclic Antidepressant Toxicity Treatment & Management. Medscape. https://emedicine.medscape.com/article/819204-treatment?form=fpf